Biosynthesis: Aromatic Polyketides, Isoprenoids, Alkaloids (Topics in Current Chemistry)

Biosynthesis: Aromatic Polyketides, Isoprenoids, Alkaloids (Topics in Current Chemistry) by -

Title: Biosynthesis: Aromatic Polyketides, Isoprenoids, Alkaloids (Topics in Current Chemistry)
Author: -
ISBN10: 3642085830
ISBN13: 978-3642085833
Publisher: Springer; Softcover reprint of the original 1st ed. 2000 edition (December 7, 2010)
Language: English
Subcategory: Engineering
Size PDF: 1576 kb
Size Fb2: 1382 kb
Rating: 4.0/5
Votes: 424
Pages: 247 pages
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Biosynthesis: Aromatic Polyketides, Isoprenoids, Alkaloids (Topics in Current Chemistry) by -


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This book is the second of two volumes that deal with discovery of chemical pathways of biosynthesis of natural products (secondary metabolites). The first volume covered the use of isotopes in biosynthetic research and the formation of enzyme cofactors and reduced polyketides. This second volume describes biosynthesis of aromatic (unreduced) polyketides, enzymes responsible for cyclization of terpenoids (isoprenoids), and biochemical generation of selected classes of alkaloids (prenylated tryptophan, tropane, pyrrolizidine). Knowledge of the pathways and the techniques to elucidate them opens the door to combinatorial biosynthesis as well as to the production of targeted pharmaceutical agents utilizing a combination of chemistry, molecular biology and protein biochemistry.