Retro-Vectors for Human Gene Therapy (Medical Intelligence Unit)

Retro-Vectors for Human Gene Therapy (Medical Intelligence Unit) by Clague P. Hodgson

Title: Retro-Vectors for Human Gene Therapy (Medical Intelligence Unit)
Author: Clague P. Hodgson
ISBN10: 3540606858
ISBN13: 978-3540606857
Publisher: Springer; 1 edition (May 2, 1996)
Language: English
Subcategory: Medicine
Size PDF: 1674 kb
Size Fb2: 1269 kb
Rating: 4.3/5
Votes: 460
Pages: 149 pages
Other Format: lit azw doc docx

Retro-Vectors for Human Gene Therapy (Medical Intelligence Unit) by Clague P. Hodgson


pdf epub fb2 djvu



This book is about retrovectors, the gene transfer systems used in 80% of ongoing clinical trials of gene therapy. Retroviruses and cellular retroelements are natural gene transfer materials that have been involved in the dispersal and regulation of genes throughout eons of evolutionary history. The retroelements (so-called because of their unique property of reverse transcribing RNA sequences into DNA and integrating them into a host chromosome) naturally comprise more than a quarter of the DNA in the human genome. They are now being adapted for an important role in gene therapy. Conventional retroviruses and vector helper systems are discussed, as well as more recently developed retrotransposon and synthetic retrovectors.