Dynamics of Cellular Motility (Nonlinear science: theory & applications)

Dynamics of Cellular Motility (Nonlinear science: theory & applications) by Masatoshi Murase

Title: Dynamics of Cellular Motility (Nonlinear science: theory & applications)
Author: Masatoshi Murase
ISBN10: 0719024269
ISBN13: 978-0719024269
Publisher: Manchester University Press (January 1, 2000)
Language: -
Subcategory: Basic Sciences
Size PDF: 1354 kb
Size Fb2: 1684 kb
Rating: 5.0/5
Votes: 438
Pages: 300 pages
Other Format: mobi lrf lrf azw

Dynamics of Cellular Motility (Nonlinear science: theory & applications) by Masatoshi Murase


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This work offers new ideas and theories to account for oscillatory contraction in muscle and the various modes of flagellar and ciliary movements. The author has developed theoretical models to interpret most of the dynamic behaviour systems. The book is intended for the use of students and specialists in biology, physics, chemistry and mathematics, as cellular motility is a subject of interdisciplinary interest. Chapter 1 gives basic examples of temporal and spatial orders. The problems of these orders are not restricted to biology, but also apply to mechanics and chemistry. Part 1 deals with the mechanical properties of vertebrate skeletal muscle and insect flight muscle. Chapter 2 describes experimental observations. Oscillatory contractions have been observed, not only in heart muscle, but also in skeletal and insect flight muscle. Common molecular mechanism for oscillation might exist in various types of muscle. Experimental results are outlined. Chapter 3 goes on to discuss some of the mathematical models for muscle contractions. Instead of giving a detailed explanation of each model, essential features are summarized. The analogy between the muscle system and the nerve system is discussed, based on this simplified model behaviour. Part 2 sketches in the self-organization of flagellar and ciliary bending patterns. Chapter 4 continues with the definition of flagella and cilia, describing their internal structure. Functional as well as structural hierarchy is discussed. Chapter 5 discusses fluid dynamical principles of ciliary and flagellar motion. The fundamental equation which governs the behaviour of a thin filament through a viscous medium is derived. Chapter 6 then discusses the molecular mechanism underlying bend initiation and propagation. Using computer simulations, the one-dimensional array of excitable units, not only exhibits symmetric beating patterns typical of flagella, but also demonstrates asymmetric beating patterns typical of cilia. Chapter 7 develops simplified models for flagellar motility, to examine whether the excitable mechanism that was studied in Chapter 6 generates bend propagation of small amplitudes.